Comparison List


mScarlet2-I is a basic (constitutively fluorescent) fluorescent protein published in 2019, derived from synthetic construct. It is reported to be a monomer.

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Oligomerization Organism Molecular Weight Cofactor
Monomer synthetic construct 25.8 kDa -

FPbase ID: PMQ1Q


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mScarlet2-I Sequence



To determine whether this improvement [replacing the N terminus with MDSTES and the C terminus with GSSGSS] extends to another FP, we examined mScarlet-I... The N-terminal peptide of mScarlet-I was replaced with MDSTEA because we found that MDSTES diminished the fluorescence (data not shown), and the C-terminal peptide was replaced with GGSGGS, yielding a variant that we termed mScarlet2-I. Although the difference between mScarlet-I and mScarlet-2I was less pronounced than the difference between mCherry and mCherry2C, the DH10B colonies expressing mSclarlet-2I were larger on average than those expressing mScarlet-I. The combined results indicate that the terminal peptides of EGFP can render some FPs cytotoxic.

Valbuena et al. (2019)

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